Abstract:

Objective To evaluate the effect of argon laser peripheral iridoplasty (ALPI) on corneal endothelium in the acute attack stage of acute angle closure glaucoma(AACG). Design Retrospective case series. Participants 162 patients with unilateral AACG successfully managed with either anti-glaucoma medication or ALPI. Methods Gender, age, pro-and post-treatment intraocular pressure (IOP), anti-glaucoma medication, corneal endothelial cell density of the patients were reviewed and analyzed statistically. Main outcome measures Loss of corneal endothelial cell, pro- and post-treatment IOP, anti-glaucoma medications of the effected eye. Results 61 cases received successful ALPI for the acute attack of AACG, with average age of 59.8±10.2 years old. The mean IOP of the effected eyes was 44.7±4.1 mmHg. In the medication group, 101 cases were included with average age of 58.6±6.1 years old. The mean IOP in the effected eyes was 45.3±4.8 mmHg. After treatment, the average IOP in ALPI group was 11±2.6 mmHg, in which the average loss of corneal endothelium was 1613±332/mm2. Mean IOP of treated AACG eyes in medication group was 14.5 ±3.1 mmHg，in which the corneal endothelial cell loss was 1321±290/mm2，which was significantly less than that of ALPI group(P=0.000). Conclusion Both ALPI and medication can arrest the acute attack of AACG, while the former may cause more corneal endothelial cell loss. (Ophthalmol CHN, 2018, 27: 291-295)

Key words: acute angle closure glaucoma/treatment, corneal endothelial cell density, argon laser peripheral iridoplasty